• Follow the Money: Cystic Fibrosis Treatment, Advancing CAR-T Candidate, Modular T Cell Engagers, More

    Clinical Research News | Sionna Therapeutics plan to develop a first-in-class small molecules designed to fully restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein by stabilizing the first nucleotide-binding domain (NBD1); Capstan Therapeutics is advancing CPTX2309, the company’s lead in vivo chimeric antigen receptor T cell (CAR-T) candidate, to early clinical proof-of-concept in autoimmune disorders; Clasp Therapeutics is developing modular T cell engagers tailored to each patient’s immune system that are directed to common oncogenic driver mutations; and more.

    Mar 26, 2024

  • Electronic White Blood Cell Tracker Developed For Near-Patient Testing

    Clinical Research News | A revolution is underway in the diagnostics world that is reminiscent of what transpired in the computing field before the advent of PCs and smartphones. The unimagined possibilities of today will come from democratizing technology so that instead of sending patients to the lab, the lab will get sent to patients—and, ultimately, be available to them in the form of at-home testing kits.

    Mar 21, 2024

  • Latest Oral Insulin Drug Making Its Way To Clinical Trials

    Clinical Research News | More than a century has passed since the discovery of insulin, the world's first life-saving treatment for diabetes, and it is still being delivered via injection despite several brushes with success in developing an oral version of the drug. Hope is again on the horizon with the emergence of an oral nanotherapeutic formulation of insulin that comes with the possibility of reducing if not eliminating hypoglycemic events.

    Mar 20, 2024

  • Discussions Begin On Properly Using Generative AI In Clinical Trials

    Clinical Research News | The question of whether generative artificial intelligence (AI) can play a role in clinical trials needs to be supplanted by questions of where and when it should be applied, according to a panel of experts speaking at last month’s Summit for Clinical Ops Executives (SCOPE) in Orlando.

    Mar 19, 2024

  • Navigating Wearable Integration: Key Operational Considerations in Clinical Trials

    Clinical Research News | Wearable devices are helping to transform the way clinical development programs are conducted, offering an innovative approach to data collection, patient monitoring, and endpoint measurement. The seamless integration of wearable technologies into trials requires meticulous consideration across various operational aspects.

    Mar 15, 2024

  • Site Selection With Data-Driven Decisions

    Clinical Research News | Finding the right trial site with access to a diverse patient population is challenging. While the clinical trial and research fields have made great efforts to overcome these challenges, there are still obstacles that slow down the process and frustrate researchers.

    Mar 13, 2024

  • New Vaccinology Rulebook Needed To Outsmart ‘Part-Time Pathogens’

    Clinical Research News | Researchers at University of California San Diego School of Medicine have found that the rules of vaccinology need to be reversed for Staphylococcus aureus (SA), the common and sometimes dangerous bacteria that humans encounter shortly after birth and are continuously exposed to for the remainder of their life.

    Mar 12, 2024

  • Study Establishes ENPP1 As A Biomarker For Immunotherapy Benefit

    Clinical Research News | Researchers in California have shown that breast cancer patients with RNA expression levels of ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) in the bottom 50th percentile can confidently be treated with Keytruda (pembrolizumab) as well as surgery.

    Mar 7, 2024

  • Five Health Systems Picking Dandelion Health To Advance Clinical AI

    Clinical Research News | If artificial intelligence (AI) is to be as insightful as possible in advancing human health, it is not enough to have a patchwork of out-of-context data from which to draw conclusions. That is unfortunately the current situation and at the cost of lost opportunities to better treat patients, identify early biomarkers of disease, and recognize the right endpoints in clinical trials—not to mention eradicating existing biases against marginalized groups of people.

    Mar 6, 2024

  • Future Looks Bright For Decentralized Clinical Trials

    Clinical Research News | Decentralized clinical trials (DCTs) today are both more fit-for-purpose and business-as-usual than uncertain and unavoidable, as was the case during the height of the COVID-19 pandemic. Among the key challenges with DCTs are keeping sites and patients engaged, dealing with the near-constant inflow of data from digital platforms and wearable devices, and quantifying the value of various decentralized study components.

    Mar 5, 2024

  • Medidata Collaboration to Deploy Vaccine Studies, New CEO at Saama, H1 Updates to AI Toolkit, More

    Clinical Research News | Medidata and Sanofi Vaccines announced a collaboration to harness Medidata eCOA to deploy in vaccine studies; H1 has launched GenosAI Pro, a new addition to its conversational AI toolkit within Trial Landscape platform; and more.

    Feb 29, 2024

  • Follow the Money: First Circular RNA-Based Clinical Assay, Oncology Programs, More

    Clinical Research News | Circular Genomics plans to build and scale commercial operations in preparation for the launch of the world's first circular RNA-based clinical assay; NextPoint Therapeutics will advance the company’s two immuno-oncology clinical programs, NPX267 and NPX887; Accent Therapeutics will use funding to support the advancement of both lead programs—Accent’s first-in-class DHX9 inhibitor and a potentially best-in-class KIF18A inhibitor; and more.

    Feb 28, 2024

  • CliniSpan Health Wins SCOPE’s Clinical Trial Tech: Startup Pitch Contest

    Clinical Research News | If artificial intelligence (AI) is to be as insightful as possible in advancing human health, it is not enough to have a patchwork of out-of-context data from which to draw conclusions. That is unfortunately the current situation and at the cost of lost opportunities to better treat patients, identify early biomarkers of disease, and recognize the right endpoints in clinical trials—not to mention eradicating existing biases against marginalized groups of people.

    Feb 27, 2024

  • Convergence of Clinical Research and Clinical Care On The Horizon

    Clinical Research News | If artificial intelligence (AI) is to be as insightful as possible in advancing human health, it is not enough to have a patchwork of out-of-context data from which to draw conclusions. That is unfortunately the current situation and at the cost of lost opportunities to better treat patients, identify early biomarkers of disease, and recognize the right endpoints in clinical trials—not to mention eradicating existing biases against marginalized groups of people.

    Feb 27, 2024

  • ClinEco Commons Launches, Offering Portal for Industry Resources, Expertise

    Clinical Research News | At SCOPE last week, ClinEco launched ClinEco Commons, the latest addition to the growing online community and marketplace designed to be the central resource for clinical research professionals worldwide, offering a comprehensive and easy-to-use portal for critical information and industry expertise.

    Feb 23, 2024

  • Next Level Supply Chain Optimization: A Strategic Approach to Managing Clinical Trial Costs

    Clinical Research News | Clinical trials have experienced tremendous innovation in the last few years. The introduction of new technologies such as wearable devices, machine learning, remote monitoring, and virtual clinical visits holds tremendous promise to expedite therapeutics to market and reduce the cost of clinical trials.

    Feb 23, 2024

  • Clinical Trial Tech – What Investors Want And Studies Need

    Clinical Research News | The perspectives of clinical trial technology investors and trends for future investment were the topics of a pair of fast-paced panel discussions at last week’s Summit for Clinical Ops Professionals (SCOPE) in Orlando. What investors want appears to be well aligned with what sponsors and sites say they need—solutions running the gamut from better matching patients to trials and improving access to streamlining the way studies get designed and conducted.

    Feb 20, 2024

  • SCOPE Summit 2024 Award Winners

    Clinical Research News | SCOPE Summit 2024 once again shined a spotlight on the breakthroughs, discoveries, and achievements of hundreds of organizations in their efforts to improve clinical trials and help patients worldwide. Three awards were presented at the conference: the Participant Engagement Award, the Site Innovation Award, and the Best of Show Award.

    Feb 15, 2024

  • Pharmaceutical Targets Identified For Osteoarthritis

    Clinical Research News | Researchers from the University of Adelaide (Australia) and the Columbia University (New York) have “reimagined” osteoarthritis, providing a pharmaceutical target for the discovery of drugs to reverse and treat the ubiquitous degenerative joint disease. Osteoarthritis was originally believed to be a “wear and tear” condition, and some people still refer to it that way, which wrongly implies that its progression is a matter of time and inevitable.

    Feb 13, 2024

  • New Products, Company News On Display at SCOPE

    Clinical Research News | The days leading up to the Summit for Clinical Ops Professionals—SCOPE—are a busy time for the clinical trials and clinical research space. The event kicked off yesterday and so far we’ve gathered these company and product news.

    Feb 12, 2024