• Classification System For Colorectal Cancer Needs An Update

    Clinical Research News | A multi-national team of clinicians and scientists has determined that the consensus molecular subtype (CMS) classification of colorectal cancer needs updating to better reflect the molecular underpinnings of the disease.

    Aug 11, 2022

  • GA4GH Phenopackets Standard Published By ISO

    Clinical Research News | The International Organization for Standardization (ISO) has published Phenopackets, a standard initially developed by the Global Alliance for Genomics and Health and championed at ISO under the Canadian Mirror Committee to ISO/TC215/SC1 Genomics informatics, and supported by the Standards Council of Canada.

    Aug 10, 2022

  • Online ‘Biclustering’ Tool Stratifies Patients To The Molecular Level

    Clinical Research News | Researchers in Germany have developed a web-based tool, powered by machine learning, which extracts disease subtypes from large pools of patient data. The goal is more precise and robust predictions about molecular signatures that can serve as a starting point for investigating disease heterogeneity.

    Aug 9, 2022

  • Walgreens’ Decentralized Clinical Trial Future

    Clinical Research News | In June, Walgreens launched its clinical trial business in an effort to combine the company’s vast foundation of patient insights, partner-enabled health and technology capabilities, and in-person and virtual care options to break through barriers to engaging broader and more diverse communities.

    Aug 4, 2022

  • Finding the Silver Lining: Data and Knowledge Sharing Through Research Data Networks

    Clinical Research News | Research communities face tremendous challenges in creating and acquiring FAIR data. In the latest Scope of Things podcast episode, Dipak Kalra, president of i~HD, talks about research data networks, navigating the pandemic, and new data regulations from the European Commission.

    Aug 2, 2022

  • Leveraging Non-Wrist Wearables for Healthcare and Clinical Trials

    Clinical Research News | Wearables enable us to measure and derive any number of digital clinical endpoints, but their value—and challenge—lies in having those endpoints validated and broadly accepted. An open-source approach to algorithm development is crucial, especially involving non-wrist wearable use cases.

    Jul 29, 2022

  • PTSD Adaptive Platform Trial, Long COVID Phenomics Research, More

    Clinical Research News | The American Heart Association hosts a six-month challenge testing heart failure and the social determinants of health; research accelerates for an NGS-based diagnostic test to identify cancer; a multi-year project enlists 10,000 people 95 and older to explore the biological and genetic underpinnings of exceptional longevity; and more.

    Jul 28, 2022

  • Follow the Money: Nutrient Control for Cancer Inhibition, Patient Engagement Research Initiative, More

    Clinical Research News | Funding for centralized patient data network research, a new landmark clinical trial for neurologically impaired children, ALS vaccine development, and more.

    Jul 27, 2022

  • Cancer Centers Measure COVID-19 Impact on Clinical Trials

    Clinical Research News | A clinical team at Dana Farber Cancer Institute and Mount Sinai explored oncology clinical trial disruption during the COVID-19 pandemic. They found that substantial disruptions early in the pandemic gradually recovered, but some lasting changes remain.

    Jul 21, 2022

  • Case Series Paves Way For Clinical Trials With Phage Therapy

    Clinical Research News | In collaboration with physicians from around the world, researchers at the University of Pittsburgh and the University of California San Diego School of Medicine recently reported on a series of 20 consecutive cases where an intractable, non-tuberculous Mycobacterium infection was treated with phage therapy over an average course of six months. More than half of those patients saw a favorable clinical or microbiological outcome.

    Jul 19, 2022

  • Milestones Easier To Meet With Integrated Clinical Trials Management System

    Clinical Research News | Until recently, clinical study teams at the Medical University of South Carolina had no system for registering participants, keeping track of upcoming study visits, or what to invoice when on industry-sponsored projects. All that is changing with implementation of a clinical trials management system, fully integrated with the university’s Research Integrated Network of Systems, in mandatory use since March 2022 for all new trials undertaken across campus.

    Jul 14, 2022

  • Tufts Study Provides ‘First Hard Metrics’ Around Decentralized Clinical Trials

    Clinical Research News | Decentralized clinical trials can deliver a higher “expected net present value” that equates to a roughly $10 million return on a $2 million investment for phase 2 trials and $39 million return on a $3 million investment for phase 3 studies. The economic savings come from reduced cycle times, improved patient screening and enrollment, and fewer protocol amendments over the life of a trial.

    Jul 13, 2022

  • Worldwide Clinical Trial, Invitae Announce RWD Platform Partnership

    Clinical Research News | Worldwide Clinical Trials and Invitae have announced a strategic partnership. Worldwide will be the first CRO to use Invitae’s Explorer tool, part of its real-world data platform that enables access to aggregated genetic testing results.

    Jul 12, 2022

  • How the World’s First Clinical Trial Market Network Saves Stakeholders Time and Money

    Clinical Research News | ClinEco–a clinical trial ecosystem and market network designed to streamline the process of identifying and selecting clinical trial partners–is the first of its kind. It reduces the cost and speed of studies by catering to the specific needs of individual sponsors and vendors.

    Jul 12, 2022

  • Drug Repurposing Strategy Without An ‘Answer Book’

    Clinical Research News | Scientists working in the information biology lab at Hokkaido University in Japan have come up with a drug repurposing strategy combining machine learning, unsupervised clustering of gene expression, and two-stage prediction.

    Jul 7, 2022

  • Clinical Trial Repurposing A Heart Drug For Non-Alzheimer’s Dementia

    Clinical Research News | A combined analysis of autopsy cohorts in 13 studies across three continents highlights growing appreciation of the heterogeneity of dementia and the critical need for clinical trials to tease out the underlying molecular mechanisms. The “inconvenient truth” is that the brain is the most complicated organ in the body and entitled to more than one aging-related disease.

    Jul 5, 2022

  • Parexel’s New Community Alliance Network, Illuminating Gut Microbiome Oncology Studies, More

    Clinical Research News | Artificial intelligence capabilities design potentially more precise and efficient clinical trials for Bristol Myers Squibb; a natural language generation platform accelerates clinical study submission processes; The University of Chicago Medicine helms a nationwide cancer study with 50,000 participants; a one-of-a-kind online tool for sharing, collecting, and analyzing data specifically about Down syndrome; and more.

    Jun 30, 2022

  • Follow the Money: Immune-Mediated Disease Therapy, Neurological Clinical Trials, More

    Clinical Research News | Funding for sepsis precision therapy, fully robotic biological data and research factory, antibody-drug conjugate therapeutics, and more.

    Jun 29, 2022

  • Clinical Trials To Benefit From New Staging System For Huntington’s Disease

    Clinical Research News | An international consortium of scientists has come up with a staging system for Huntington’s disease that tracks with its underlying biological, clinical, and functional characteristics in patients, as seen in those participating in four large prospective cohort studies.

    Jun 28, 2022

  • How AI and Computer Vision Can Solve Challenges in IBD Drug Development

    Clinical Research News | Advances in artificial intelligence-driven algorithms and computer vision can address bottlenecks that sponsors and physician investigators face in developing therapeutic options and matching inflammatory bowel disease (IBD) patients with a clinical trial.

    Jun 24, 2022